Liver disease

1. Step 1 · Hepatology

   FIB-4 Index for Liver Fibrosis

   First-line fibrosis triage in MASLD or viral hepatitis.

   Population

   Adults ≥ 35

   Key limitation

   Indeterminate zone.

   Inputs

   5

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2. Step 2 · Hepatology

   APRI (AST to Platelet Ratio Index)

   Alternative fibrosis index, especially hepatitis C.

   Population

   Chronic hepatitis C

   Key limitation

   Moderate accuracy.

   Inputs

   3

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3. Step 3 · Hepatology

   Child-Pugh Score for Cirrhosis

   Cirrhosis severity, drug dosing and surgical risk.

   Population

   Cirrhosis

   Key limitation

   Subjective items.

   Inputs

   5

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4. Step 4 · Hepatology

   MELD 3.0 (Model for End-Stage Liver Disease)

   Transplant prioritisation and short-term prognosis in end-stage liver disease.

   Population

   Adult transplant candidates

   Key limitation

   Wait-list mortality, not post-transplant outcome.

   Inputs

   7

   Open tool

5. Step 5 · Hepatology

   Maddrey's Discriminant Function

   Severity of alcohol-associated hepatitis.

   Population

   Alcohol-associated hepatitis

   Key limitation

   PT reagent variability.

   Inputs

   3

   Open tool

The Navigator organises validated tools around a presentation. It does not recommend a diagnosis or treatment.