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About this tool
Five-component score (bilirubin, albumin, INR, ascites, encephalopathy) grading cirrhosis into classes A–C.
Intended use
Patients with cirrhosis — prognosis, drug dosing and surgical risk.
Outcome
Cirrhosis severity / survival
Time horizon
1–2 years (classically)
Derivation population
Originally patients undergoing portosystemic shunt surgery / oesophageal transection.
Limitations
- Ascites and encephalopathy grading are subjective.
- Ceiling effects at each component.
Clinical problems
Evidence
Evidence level
Moderate evidence
Long-established and used in drug labelling; derived empirically in surgical cohorts. Methodology
References
- Original publicationPugh RN, Murray-Lyon IM, Dawson JL, Pietroni MC, Williams R. Transection of the oesophagus for bleeding oesophageal varices. Br J Surg 1973;60:646-649. Find on PubMed (opens in a new tab)
- Original publicationChild CG, Turcotte JG. Surgery and portal hypertension. Major Probl Clin Surg 1964;1:1-85. Find on PubMed (opens in a new tab)
Version history
| Version | Formula | Effective | Reviewer | Changes |
|---|---|---|---|---|
| v1.0.0 | Pugh 1973 | 2026-10-03 | — | Initial implementation with reference test vectors. |
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Clinical decision support only. Interpret results in the context of the individual patient and current guidance; HumanPulse does not replace professional medical judgment.