Cardiology Risk score Moderate evidence Clinical review pending v1.0.0

GRACE Risk Score — 6-month Post-discharge Death

What is the risk of death within 6 months after discharge for acute coronary syndrome?

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About this tool

Nine-variable GRACE Cox model for death within 6 months of hospital discharge in survivors of acute coronary syndrome, shown as model probability and integer score.

Intended use

Patients surviving hospitalisation for acute coronary syndrome, at discharge.

Outcome

All-cause death from discharge to 6 months

Time horizon

6 months after discharge

Derivation population

Hospital survivors of ACS in the Global Registry of Acute Coronary Events.

Do not use in

Patients who died in hospital; patients without ACS.

Limitations

Derived in an older registry population; absolute risks may be lower with contemporary care.
GRACE 2.0 long-term models are not implemented.

Evidence

Evidence level

Moderate evidence

Derived and validated in large registry cohorts; superseded for long-term prediction by GRACE 2.0. Methodology

Geographic applicability

Multinational registry.

Evidence summaries for this tool are awaiting independent clinical review. Statistics are shown only where they could be attributed to a specific publication.

References

Original publicationEagle KA, Lim MJ, Dabbous OH, et al. A validated prediction model for all forms of acute coronary syndrome: estimating the risk of 6-month postdischarge death in an international registry. JAMA 2004;291:2727-2733. Find on PubMed (opens in a new tab)
Review / updateGRACE Coordinating Center. Methods and formulas used to calculate the GRACE Risk Scores for patients presenting to hospital with an acute coronary syndrome. Center for Outcomes Research, University of Massachusetts Medical School; updated 30 January 2014. Find on PubMed (opens in a new tab)

Version history

Version	Formula	Effective	Reviewer	Changes
v1.0.0	Eagle 2004 Cox model and nomogram, per GRACE Coordinating Center methods (2014)	2026-10-03	—	Initial implementation with reference test vectors.

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Clinical decision support only. Interpret results in the context of the individual patient and current guidance; HumanPulse does not replace professional medical judgment.