SIRS Criteria
Does the patient meet criteria for the systemic inflammatory response syndrome?
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About this tool
Four physiological criteria; two or more define SIRS.
Intended use
Adults with suspected infection or other inflammatory insult.
Outcome
SIRS present / absent
Time horizon
Point in time
Derivation population
ACCP/SCCM consensus definition.
Limitations
- Sensitive but not specific; many hospitalised patients meet SIRS without infection.
- Superseded for sepsis definition by Sepsis-3 (SOFA-based).
Clinical problems
Evidence
Evidence level
Moderate evidence
Consensus definition rather than a derived prediction model. Methodology
References
- Original publicationBone RC, Balk RA, Cerra FB, et al. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. Chest 1992;101:1644-1655. Find on PubMed (opens in a new tab)
Version history
| Version | Formula | Effective | Reviewer | Changes |
|---|---|---|---|---|
| v1.0.0 | ACCP/SCCM 1992 | 2026-10-03 | — | Initial implementation with reference test vectors. |
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Clinical decision support only. Interpret results in the context of the individual patient and current guidance; HumanPulse does not replace professional medical judgment.