Nephrology Equation Moderate evidence Clinical review pending v1.0.0

Creatinine Clearance — Cockcroft-Gault

What is the estimated creatinine clearance for drug dosing?

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About this tool

Estimated creatinine clearance (mL/min), with optional ideal and adjusted body-weight variants.

Intended use

Adults with stable creatinine, mainly for drug dosing where labels specify Cockcroft-Gault.

Outcome

Creatinine clearance

Time horizon

Point in time

Derivation population

249 adult male Veterans Affairs inpatients (1976).

Limitations

Derived before creatinine standardisation; overestimates in obesity with actual weight.
Female correction (0.85) was assumed, not measured.

Clinical problems

Kidney function and AKI

Evidence

Evidence level

Moderate evidence

Established equation still specified in many drug labels; less accurate than CKD-EPI for GFR. Methodology

Evidence summaries for this tool are awaiting independent clinical review. Statistics are shown only where they could be attributed to a specific publication.

References

Original publicationCockcroft DW, Gault MH. Prediction of creatinine clearance from serum creatinine. Nephron 1976;16:31-41. Find on PubMed (opens in a new tab)

Version history

Version	Formula	Effective	Reviewer	Changes
v1.0.0	Cockcroft & Gault 1976; Devine IBW	2026-10-03	—	Initial implementation with reference test vectors.

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Clinical decision support only. Interpret results in the context of the individual patient and current guidance; HumanPulse does not replace professional medical judgment.