Framingham General Cardiovascular Risk (2008)
What is the 10-year risk of any first cardiovascular event?
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About this tool
Sex-specific general cardiovascular disease risk function from the Framingham Heart Study (lipid version), predicting coronary, cerebrovascular, peripheral arterial and heart-failure events.
Intended use
Adults aged 30–74 without cardiovascular disease at baseline.
Outcome
General CVD (coronary death, MI, coronary insufficiency, angina, stroke, TIA, PAD, heart failure)
Time horizon
10 years
Derivation population
Framingham Original and Offspring cohort participants aged 30–74, free of CVD at baseline.
Do not use in
Established cardiovascular disease.
Limitations
- Predominantly white US cohort; may overestimate risk in some populations.
- Broad outcome definition gives higher values than hard-ASCVD models.
Evidence
Evidence level
Moderate evidence
Long-established and widely validated model; calibration varies across populations. Methodology
Geographic applicability
United States (predominantly white cohort).
References
- Original publicationD'Agostino RB Sr, Vasan RS, Pencina MJ, et al. General cardiovascular risk profile for use in primary care: the Framingham Heart Study. Circulation 2008;117:743-753. Find on PubMed (opens in a new tab)
- Review / updateFramingham Heart Study. Cardiovascular Disease (10-year risk) — published coefficients and calculator. Source (opens in a new tab)
Version history
| Version | Formula | Effective | Reviewer | Changes |
|---|---|---|---|---|
| v1.0.0 | D'Agostino 2008 lipid model; coefficients per framinghamheartstudy.org | 2026-10-03 | — | Initial implementation with reference test vectors. |
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