HOMA-IR (Homeostatic Model Assessment of Insulin Resistance)
What is the estimated insulin resistance from fasting glucose and insulin?
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About this tool
Simple homeostatic model estimate of insulin resistance.
Intended use
Research and population-level assessment; not for individual diagnosis.
Outcome
Insulin resistance index
Time horizon
Point in time
Limitations
- No universal cut-off.
- Insulin assays vary.
Evidence
Evidence level
Limited evidence
Derivation and limited validation only, or significant known calibration problems. Methodology
Evidence summaries for this tool are awaiting independent clinical review. Statistics are shown only where they could be attributed to a specific publication.
References
- Original publicationMatthews DR, Hosker JP, Rudenski AS, et al. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985;28:412-419. Find on PubMed (opens in a new tab)
Version history
| Version | Formula | Effective | Reviewer | Changes |
|---|---|---|---|---|
| v1.0.0 | Matthews 1985 | 2026-10-03 | — | Initial implementation with reference test vectors. |
Related tools
Clinical decision support only. Interpret results in the context of the individual patient and current guidance; HumanPulse does not replace professional medical judgment.