Emergency Medicine Risk score Strong evidence Clinical review pending v1.0.0

Simplified PESI (sPESI)

Is a patient with acute PE at low risk of 30-day mortality?

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About this tool

Six-item simplification of PESI separating low-risk (0) from higher-risk (≥ 1) patients with acute PE.

Intended use

Adults with confirmed acute PE.

Outcome

All-cause mortality

Time horizon

30 days

Derivation population

Spanish RIETE registry and multicentre cohort.

Limitations

Binary output; does not replace assessment of RV function in intermediate-risk patients.

Clinical problems

Suspected pulmonary embolism

Evidence

Evidence level

Strong evidence

Derived and externally validated in multiple cohorts (including prospective studies) and incorporated into major clinical guidelines. Methodology

Guideline status

Used alongside PESI in the 2019 ESC acute PE guideline.

Validation studies

Derivation cohort (Jiménez 2010)

995 patients

30-day mortality 1.0% with sPESI 0 vs 10.9% with sPESI ≥ 1.

Evidence summaries for this tool are awaiting independent clinical review. Statistics are shown only where they could be attributed to a specific publication.

References

Original publicationJiménez D, Aujesky D, Moores L, et al. Simplification of the Pulmonary Embolism Severity Index for prognostication in patients with acute symptomatic pulmonary embolism. Arch Intern Med 2010;170:1383-1389. Find on PubMed (opens in a new tab)

Version history

Version	Formula	Effective	Reviewer	Changes
v1.0.0	Jiménez 2010	2026-10-03	—	Initial implementation with reference test vectors.

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Clinical decision support only. Interpret results in the context of the individual patient and current guidance; HumanPulse does not replace professional medical judgment.