Kidney function and AKI

1. Step 1 · Nephrology

   eGFR — CKD-EPI 2021 Creatinine Equation

   Estimate GFR and KDIGO category in stable kidney function.

   Population

   Adults

   Key limitation

   Not valid in AKI.

   Inputs

   3

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2. Step 2 · Nephrology

   Creatinine Clearance — Cockcroft-Gault

   Creatinine clearance for drug dosing when labels specify it.

   Population

   Adults

   Key limitation

   Weight choice matters.

   Inputs

   5

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3. Step 3 · Nephrology

   Kidney Failure Risk Equation (4-variable)

   Risk of kidney failure in CKD G3–G5 to time referral and planning.

   Population

   CKD G3–G5

   Key limitation

   Ignores competing risk of death.

   Inputs

   5

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4. Step 4 · Nephrology

   Fractional Excretion of Sodium (FENa)

   Oliguric AKI without diuretics — prerenal vs intrinsic.

   Population

   Oliguric AKI

   Key limitation

   Many confounders.

   Inputs

   4

   Open tool

5. Step 5 · Nephrology

   Fractional Excretion of Urea (FEUrea)

   AKI with diuretics — prerenal vs intrinsic.

   Population

   AKI on diuretics

   Key limitation

   Lower accuracy in sepsis.

   Inputs

   4

   Open tool

The Navigator organises validated tools around a presentation. It does not recommend a diagnosis or treatment.