Hematology Risk score Moderate evidence Clinical review pending v1.0.0

PLASMIC Score for Thrombotic Thrombocytopenic Purpura

How likely is severe ADAMTS13 deficiency (TTP) in a patient with thrombotic microangiopathy?

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About this tool

Seven-item score predicting severe ADAMTS13 deficiency before results are available.

Intended use

Adults with suspected thrombotic microangiopathy.

Outcome

Severe ADAMTS13 deficiency (activity < 10%)

Time horizon

Current episode

Derivation population

US multi-institutional TMA registry.

Limitations

Validated in adults only.
Does not replace ADAMTS13 testing.

Clinical problems

Cytopenias and thrombosis

Evidence

Evidence level

Moderate evidence

Externally validated, or an established physiological equation whose clinical thresholds rest on consensus; guideline support limited or mixed. Methodology

Evidence summaries for this tool are awaiting independent clinical review. Statistics are shown only where they could be attributed to a specific publication.

References

Original publicationBendapudi PK, Hurwitz S, Fry A, et al. Derivation and external validation of the PLASMIC score for rapid assessment of adults with thrombotic microangiopathies: a cohort study. Lancet Haematol 2017;4:e157-e164. Find on PubMed (opens in a new tab)

Version history

Version	Formula	Effective	Reviewer	Changes
v1.0.0	Bendapudi 2017	2026-10-03	—	Initial implementation with reference test vectors.

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Clinical decision support only. Interpret results in the context of the individual patient and current guidance; HumanPulse does not replace professional medical judgment.